Supplemental figures and table (PDF, 384 KB), https://doi.org/10.1182/blood-2017-03-769620. Results from RCTs have demonstrated that the findings of preclinical studies have carried through to clinical practice. Herbrecht R et al. To understand the relatively favorable outcomes of some of the clinically defined subgroups in this data set, biomarkers such as cell of origin or the presence of chromosomal translocations involving BCL-2 and C-MYC (double-hit lymphomas) would be required36 ; such an evaluation of biology of patients in the SCHOLAR-1 study cohorts is planned. Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. Our results confirm our assumptions built on these earlier studies, that patients do indeed have poor outcomes, regardless of refractory subgroup.
For example, the time period of patients’ treatment may influence the applicability of the benchmark to future studies. dexamethasone, cytarabine, cisplatin; DLBCL: diffuse large B-cell lymphoma; EFS: event-free survival; Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. These results showed that 20% of patients remained alive at 2 years; however, these long-term durable responses were primarily driven by the minority of patients who received ASCT and/or achieved a CR or PR and who represent the tail of the Kaplan-Meier curve of OS.
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